This study enrolls people who have mitral regurgitation (MR). Mitral regurgitation happens when the heart’s mitral valve does not close tightly. The purpose of this trial is to evaluate a new investigational device called the Tendyne™ Mitral Valve System. The Tendyne Mitral Valve System is designed for the treatment of a diseased, damaged or malfunctioning mitral valve. This trial will collect information on how safe and effective this device is to treat a leaking mitral valve compared to the commercially available MitraClip® System. Read More
-Adults ages 18+.
-Have symptomatic, moderate-to-severe/severe mitral regurgitation (MR) or severe mitral annular calcification (MAC)
-Your medical providers have decided a transcatheter therapy is more appropriate than open surgery.
This study enrolls people who need tube shunt implantation for the treatment of their severe glaucoma. The purpose of this study is to learn which type of tube shunt (a device used during the surgery) works the best. Read More
Adults ages 18+.
Have significant uncontrolled glaucoma despite medical, laser or previous surgery that requires tube shunt implantation.
Are scheduled for glaucoma tube shunt implantation surgery.
This study enrolls high school students and teachers. The purpose of the study is to help students learn how to culture microbial organisms found in water samples from streams, rivers or lakes, and to teach about genome annotation, DNA sequencing and genomic DNA isolation. The study is also meant to help students learn more about scientific and health-related careers. Read More
-High School Biology (grades 9-12) teachers from Allegany, Cattaraugus, Chautauqua, Erie, Genesee, Livingston, Monroe, Niagara, Ontario, Orleans, Steuben, Wayne, Wyoming and Yates counties/schools.
-Teachers must recruit their students; students cannot enroll in the study on their own.
This study enrolls people who are HIV positive who are taking certain medication. If a person take Stribilid® or Genvoya®, there may be changes in the way their body uses or removes other medications. We want to study another approved treatment, Biktarvy®, that we believe is less likely to affect how the body handles other medications that a person is currently taking. This switch may improve quality of life. Read More
-Adults ages 18+.
-Positive for HIV.
-Taking current antiretroviral therapy GenvoyaTM or StribildTM for HIV-1 infection.
-Taking at least 1 or more other prescription medications.
This study is looking for women ages 18-24 who are in college. The purpose of this study is to get feedback about program designed for friends to help protect one another against sexual assault. Read More
Adult women ages 18-24.
Enrolled in a 4 year college or university
This study enrolls people who have been diagnosed with head and neck cancer and are being treated with neck radiation therapy. The purpose of this study is to find out the number of people who develop narrowing of their carotid arteries (Carotid Artery Stenosis) due to neck radiation and understand how tobacco use and diabetes effect the worsening of carotid artery stenosis. Read More
Adults age 18+
Diagnosis of neck cancer and undergoing one-sided neck radiation
Must have no history of stroke
This study enrolls adults with bipolar disorder that is currently not well controlled who will be starting treatment. The purpose of the research is to learn about the relationship between changes in the amount of calcium in platelets and mood change in people with bipolar disorder. Read More
Adults ages 18-75
Healthy, diagnosed with bipolar disorder (mania, bipolar depression, or mixed state)
Acutely ill and initiating a new standard of care treatment for their bipolar disorde
We are looking for adults in romantic relationships whose partners drink alcohol. This interview study is being done to learn more about the ways that individuals may interact with their romantic partners regarding their partner’s drinking. Participation involves a brief online questionnaire and a one-time individual online interview conducted. Interviews will last approximately 60 minutes, and participants will be compensated with a $30 gift card. Read More
Adults ages 18+
In a romantic relationship
Living with your spouse/partner
Your partner drinks alcohol
This study enrolls healthy, physically-active adults. The purpose of this study is to learn if exercising in a hot environment can better help the body adjust to higher altitudes where the air is thinner. Travel to higher altitudes takes weeks for the body to adjust, however, military personnel may not have enough time to adjust. This study may lead to valuable information that can benefit our troops. Read More
Healthy males aged 18-29
Physically-active and in good fitness