This study enrolls adults with bipolar disorder that is currently not well controlled who will be starting treatment. The purpose of the research is to learn about the relationship between changes in the amount of calcium in platelets and mood change in people with bipolar disorder. Read More

Adults ages 18-75
Healthy, diagnosed with bipolar disorder (mania, bipolar depression, or mixed state)
Acutely ill and initiating a new standard of care treatment for their bipolar disorde

We are looking for adults in romantic relationships whose partners drink alcohol. This interview study is being done to learn more about the ways that individuals may interact with their romantic partners regarding their partner’s drinking. Participation involves a brief online questionnaire and a one-time individual online interview conducted. Interviews will last approximately 60 minutes, and participants will be compensated with a $30 gift card. Read More

Adults ages 18+
In a romantic relationship
Living with your spouse/partner
Your partner drinks alcohol

This study enrolls professional ice-hockey players. The purpose of this study is to determine if the Buffalo Concussion Physical Examination is useful for diagnosing concussions and recovery from concussion of professional hockey players. Read More

Professional Ice Hockey players age 18-45
No neurological problems or history of severe brain injury

People will be invited to take part in a research study because their child is undergoing a urologicsurgical procedure that requires anesthesia and mechanical ventilation. The purpose of this study is to learn exactly how much air an alternative device to a ventilator, called a biphasic chest cuirass, provides. Read More

Children ages 6 months-5 years.
Will be having a urologicsurgical procedure (circumcision, hypospadias repair, or orchidopexy) in the operating room of the John R. Oishei Children’s Hospital.

This study enrolls healthy, physically-active adults. The purpose of this study is to learn if exercising in a hot environment can better help the body adjust to higher altitudes where the air is thinner. Travel to higher altitudes takes weeks for the body to adjust, however, military personnel may not have enough time to adjust. This study may lead to valuable information that can benefit our troops. Read More

Healthy males aged 18-29
Physically-active and in good fitness

This study enrolls adults ages 55-90 who have concerns about memory. The purpose of the Memory Improvement Through Nicotine Dosing (MIND) study is to learn whether Nicotine absorbed through the skin through a daily nicotine patch improves attention, learning, and memory in folks with mild cognitive impairment. Read More

Adults ages 55-90.
Must be a non-smoker.
Must have a memory concern as reported by participant, study partner, or clinician.
Study Partner is available who has frequent contact with the participant (e.g. an average of 10 hours per week or more), and can accompany the participant to most visits to answer questions about the participant.

This study enrolls children and adults who have tested positive for COVID-19. The purpose of this study is to collect and bank blood samples of people who have COVID-19. We will analyze these samples to understand more about the virus. Read More

Adults or children
Positive for SARS-CoV-2 or highly suspicious for SARS-CoV-2 (symptoms with known contact).

This study enrolls adults who are having a cardiac or cerebrovascular procedure that uses a device called a transcranial doppler. This study is collecting data to look at the changes in blood flow during these procedures. The data collected will help researchers develop techniques and strategies to minimize risk for stroke for future patients. Your participation in the study will not involve anything in addition to the care you are already getting- the study collects information that is already being collected as part of your care. We expect that you will be in this research study for few days until your discharge from the hospital up to your 3 month follow up visit. This study takes place only at Buffalo General Medical Center and Gates Vascular Institute. Read More

Patients who have had a cardiac or cerebrovascular procedure using TCD monitoring at Buffalo General Medical Center or Gates Vascular Institute.
Only patients who have been invited to join this study by a study team member may enroll.

We are looking for adults ages 18+ coming into Kaleida Health’s Gates Vascular Institute who have recently had a certain kind of mild stroke for this study (acute ischemic stroke that presents with mild symptoms). You would need to be enrolled into the study within 6 hours of when your symptoms begin. The purpose of this study is to find out which factors associated with the stroke make the condition worse. This will help us identify high-risk patients in the future. You will participate in this study for about 90 days. During the study you will not be asked to do anything additional- all the procedures involved in this study are routinely done with patients with stroke. If you decide to be in this study, we will gather data (for example, your history and vital signs) from your medical Read More

Age 18+.
Diagnosed with acute ischemic stroke.
At Kaleida Health-Gates Vascular Institute.
Enrolled within 6 hours from when symptoms begin.

This study enrolls children who are admitted to the pediatric intensive care unit. The purpose of this study is to learn about the effects of blood transfusion on multiple organ dysfunction syndrome (MODS). Patient’s participation in this study will involve giving blood and urine samples and chest x-rays. During the study, we will store and analyze participant’s blood and urine to measure certain protein levels and collect information about their genetic material (DNA). Compensation is not available for this study. Read More

Children ages 1 month to 18 years who are admitted to the pediatric intensive care unit.
Critically ill pediatric patients receiving blood transfusion who have an expected length of stay after transfusion in the ICU of more than 24 hours (based on the best judgment of the attending ICU staff).