Purpose: To study the effect of CHRFAM7A alleles on human monocyte derived macrophage functionSpecific Aim 1: Determine the effects that CHRFAM7A alleles have on in vitro monocyte/macrophage function by exogenous stimuli. Specific Aim 2: Determine the effects that CHRFAM7A alleles have on immune response measured by cytokine response and monocyte/macrophage function before and after in vivo vaccine administration.
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