Big Perio: Osteoimmunological Impact of Obesity in Periodontitis Pilot and Feasibility Study
The University at Buffalo (UB) School of Dental Medicine is looking for adults to participate in a dental study. The goal of this study is to better understand the link between weight status and gum disease.
Both lean and overweight participants with and without gum disease will be recruited for this study. Eligible participants will attend two study visits on the UB South Campus (at Main Street and Bailey Avenue). The study first visit will take about 2-2.5 hours to complete and the second appointment will take about 45 minutes to complete.
During the study visit, participants will answer questions about their medical and dental histories; have height and weight measurements taken; provide blood, saliva and plaque samples. Also, a full comprehensive dental exam will be completed by a trained dental hygienist. X-rays will be taken if the patient does not have copies within one year of appointment. At the second appointment, a complete bone density test will be performed and fecal samples will be collected.
Consideration will be made for participants who will be traveling a longer distance to complete the study in one visit.
Compensation is provided.
(CSR #180623704206) This is a pilot study for preliminary data to support a larger NIH application to address the potential role of specific white blood cells (MDSCs) that are expanded in obesity and determine if their expansion and/or capacity to become osteoclasts correlates with periodontal disease severity in obese versus lean controls.
Compensation may include cash, checks, gift cards, debit cards, or incentives like gift baskets, technology items, or merchandise.
Adults aged 30 to 64 years old
Either lean or overweight
Have at least 10 teeth
Have not taken an antibiotic within the last 3 months
Are not currently pregnant
Report no autoimmune disease
Are not taking immunosuppressant medication
Fluent in English or Spanish
Let us know how the study team can reach you. If you do not hear back within 2 business days, reach out to the study team directly at the
contact information above or email firstname.lastname@example.org and someone will assist you.
Your information will be shared only with the research study team for recruitment purposes and designated CTSI personnel for project quality
assurance and will remain confidential. Your information will be stored indefinitely. Should you no longer want this information to be provided
in the aforementioned ways, please contact email@example.com.